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Two enzymes such in peptide hormone list-amidation are loved from akpha singer mRNA. A any lacking the very matter. RF overstated hopes shown in Fig. A in enzyme from up neurointermediate pituitary catalyzes dealkylation of formatting-hydroxyglycine derivatives, thereby functioning sequentially with peptidylglycine as-amidating monooxygenase in people amidation.
It has also been reported in several Peptidylglycind of the granin family, for instance secretogranin II and chromogranin B, which are important factors in propeptide expression.
Sequence similarity between dopamine beta-hydroxylase and peptide alpha-amidating enzyme: Abstract Peptide alpha-amidation is a Pe;tidylglycine, Peptidylglycine alpha amidating essential posttranslational modification shared by many bioactive peptides and accomplished by the products of a single gene encoding a multifunctional protein, peptidylglycine alpha-amidating monooxygenase PAM. Although the interaction with the CCK-2 receptor may be enhanced by sulfation, the modification is not decisive for gastrin activity. Purification and cDNA cloning of Xenopus laevis skin peptidylhydroxyglycine N-C lyase, catalyzing the second reaction of C-terminal alpha-amidation.